West Midlands Ambulance Service was called to the B4086 Banbury Road, between Kineton and the Ministry of Defence site at about 5.30am this morning (Tuesday).
An ambulance and a paramedic officer were sent to the scene.
A West Midlands Ambulance Service spokesman said: “On arrival, crews found a small white van that had hit a tree and was in a ditch.
“Unfortunately, it quickly became apparent that there was nothing that could be done to save the driver and he was confirmed dead at the scene.”