Perkins, who lives in Warwick but fights out of Stratford ABC, was drawn against Adrianna Finch of Boston ABC in the 46kg category.
Perkins dominated the fight, producing a stunning right-cross in the third round to force Finch to take a staning count.
And, after claiming a unanimous decision, Perkins said it was a victory for perseverence.
“I’m over the moon to be national champion,” she said. “It’s been such a big dream of mine for the past three years.
“I’ve had my ups and downs during that time but never gave up on my dream.
“Hard work and dedication will always show in the end.”
Perkins is now hoping to fight internationally in the new year with her ultimate goal of securing one of only nine female places on the GB squad.
To help her achieve her aim, she is looking for sponsors.
Anyone interested should contact her coach Mat Pickering on 07792 636690 or Lydia Turpin on 07799 667497.