Mayne, a lecturer at Coventry University, will be one of over 1,000 transplant athletes taking part in Argentina to raise awareness both in the UK and internationally, for the need for organ donors, and to mark their second chance at life.
Mayne, who underwent a kidney transplant in 2013, will be battling for a medal in three sports - volleyball, badminton and table tennis - after claiming bronze, silver and gold medals at the British Transplant Games.
He said: “The Games have played an important role in helping me live a full and active life following my successful transplant from my brother, who offered me one of his kidneys.
“This event is a vital part of the rehabilitation process and gives all competitors a focus, as well being a place to celebrate the gift of life and an opportunity to thank our donors and their families.
“The whole team is looking forward to the buzz and excitement and plan to bring back a load of medals.”
The World Transplant Games, supported by the International Olympic Committee, represents the largest organ donor awareness event in the world, featuring a week of 13 sporting events.
Lynne Holt, team manager and trustee at Transplant Sport, said: “The World Transplant Games is a great opportunity for our transplant athletes to compete at an international level and to share their stories and inspire people to sign up to the NHS Organ Donor Register.
“Not only are these athletes ambassadors for our country, but they are also representing the charity, Transplant Sport, and hope to raise more awareness here in the UK and globally, of the need for more people to sign on to the Organ Donor Register and express their wishes with family and friends.”
The World Transplant Games takes place in Mar del Plata, Argentina, from August 23-30.